Hormone supplementation (HRT) is very useful as treatment for menopause and postmenopausal osteoporosis, and we go to many women in our hospital.HRT's central drug is estrogen preparation, but if this is the only, the risk of endometrial growth and uterine cancer increases.Therefore, in order to reduce the growth of endometriosis tissue and reduce the risk of uterine cancer, those with uterus must use progesterone preparations.This time, we will tell you how to select progesterone preparations combined with estrogen preparations at this time.
First Candidate: "Fumeno Capsule" (natural type)
The natural type is the same structure as the progesterone synthesized in the ovaries, and is currently the mainstream in the world.However, there are not many uses in Japan because it has just been released in November 2021.Nevertheless, in abundant overseas data, the endometrial proliferation suppression effect is comparable to Japan's standard "Probera Tablets" and has no risk of breast cancer, so it is considered an ideal progesterone agent in HRT.increase.In particular, I think it is useful for menopause because it has the effect of suppressing swelling and adoption to promote sleep.In our hospital, for those who start a new HRT, "Fumeno Capsule" is the first choice.
Second Candidate: "Dinagest Tablets" (synthetic type similar to natural type)
Estrogen preparations include the effects of the brain nerve cell cells and the arteriosclerosis prevention effect.However, it has been found that the combination of "Probera Tablets" will offset these desirable effects.Originally, natural type was desirable, but before it was released in Japan, the number of cases using "Dinagest Tablets", which is similar to the natural type, was increasing.However, the effect of suppressing the uterine tissue proliferation has a slightly weaker impression than "Probera Tablets", and many people acknowledge irregular bleeding.In the future, there may be cases where it will be switched to "Fumeno Capsule", but if you have a good condition with "Dinagest Tablets", it will be relatively cheap in terms of cost, so this hospital will continue to use it.intend to do something.
Third candidate: "Probera Tablets" (typical synthetic type)
"Probera Tablets" is a typical synthetic drug used for HRT, and has a strong uterine endometrial proliferation inhibitory effect, and has the impression that it is unlikely to cause irregular bleeding.However, as mentioned above, there are disadvantages, such as canceling some of the benefits of estrogen preparations and increasing the risk of breast cancer with long -term taking.We are currently planning to continue the prescription for those who are in good condition with "Probera Tablets", but if you have been taking clothes for more than 5 years, switch to "Fumeno Capsules" to reduce breast cancer risk.I am considering that.
"Fumeno Capsule" has just been released and can only be prescribed for 28 days until November 2022.In addition, it has a hypnotic effect and is taken before bedtime, so it may not be suitable for irregular work, such as night shift.In our hospital, we will keep trying to select a progesterone preparation for each patient.